Treatment monitoring using FDG-PET/CT and FLT-PET/CT in patients with Hodgkin Lymphoma

Update Il y a 4 ans
Reference: EUCTR2009-017587-16

Woman and Man

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Extract

The principal objective is to find a method for predicting at the earliest time possible (after receiving only one cycle of chemotherapy) if chemotherapy will work in patients with Hodgkin Lymphoma receiving ChlVPP chemotherapy This study will assess and compare the ability of FDG-PET/CT and FLT-PET/CT imaging in predicting, after only one cycle of treatment, the response of patients to the chemotherapy being administered. This is possible by comparing changes in tumour uptake of glucose by using FDG-PET/CT scans done before treatment, after one cycle and at completion of chemotherapy treatment. Also by assessing changes in tumour cell division by using FLT-PET/CT scans done before treatment, after one cycle and at completion of chemotherapy treatment. The working hypothesis is that it would be possible to use the changes recorded by each modality to predict individual patient response early during treatment and to test whether FLT is better than FDG at predicting this respons


Inclusion criteria

  • Hodgkin lymphoma

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