HiLo: Multicentre randomised phase III clinical trial of high versus low dose radioiodine, with or without recombinant human thyroid stimulating hormone (rhTSH), for remnant ablation following surgery...

Update Il y a 4 ans
Reference: EUCTR2005-003687-37

HiLo: Multicentre randomised phase III clinical trial of high versus low dose radioiodine, with or without recombinant human thyroid stimulating hormone (rhTSH), for remnant ablation following surgery for differentiated thyroid cancer

Woman and Man

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Extract

The main objectives of the trial are: (i) to determine whether a low dose of radioactive iodine (1.1 GBq) is as effective as the commonly used high dose (3.7GBq) in ablating any remaining thyroid tissue after surgery (ii) to determine whether taking recombinant human thyroid stimulating hormone (rhTSH) has no adverse effect on radioactive iodine ablation of the thyroid remnant compared to the current practice of withdrawing thyroid hormone 2−4 weeks before radioiodine ablation.


Inclusion criteria

  • Differentiated thyroid cancer (DTC)

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