Extrait

The main objective of this study is to determine whether a milk thistle extract (Legalon), taken with a meal containing non-haem iron, leads to a reduction in serum iron increase following the meal.

Critère d'inclusion

• Type 1 hereditary haemochromatosis is associated with homozygous inheritance of the C282Y mutation in the HFE gene. The phenotype is characterised by increased serum iron levels, tissue iron accumulation and may result in liver fibrosis, cirrhosis, and liver carcinomas. Treatment initially involves removal of one unit of blood per week to remove body iron burden, then removal of one unit of blood 2-6 times per year to prevent the re-accumualtion of iron stores

Liens

• euctr
• ictrp