Extrait

Background and study aims Smokers have worse gum disease and are more likely to lose teeth than non-smokers. When smokers stop smoking, the condition of their gums changes and become similar to a non-smoker. E-cigarettes contain nicotine and are gaining popularity, but we do not know what e-cigarettes do to the gums. We plan to study the gum condition of smokers with mild gum disease who stop smoking cigarettes for 2 weeks and use e-cigarettes instead. Gum disease can change the amount of certain chemicals in the blood, saliva and the fluid that collects in the crevice between the gum and the tooth. The amount of those chemicals changes when people stop smoking, but we do not know what happens to them when e-cigarettes are used. Who can participate? Smokers with mild gum disease who do not intend to quit smoking but would be prepared to substitute e-cigarettes instead of smoking for 2 weeks What does the study involve? We measure the gum condition of a group of smokers who do not intend to quit smoking. We also take blood from a vein in the arm, collect saliva and the fluid that collects in the crevice between the gum and the tooth. The smokers stop smoking cigarettes for 2 weeks and we provide e-cigarettes for them to use instead. After 2 weeks we measure the gum condition again and collect samples of blood, saliva and gum fluid again. What are the possible benefits and risks of participating? There are no particular benefits for people who take part except to try out e-cigarettes at no cost to themselves. There are also no particular risks except minor discomfort during the gum examination and during collection of blood. Where is the study run from? King's College London (UK) When is the study starting and how long is it expected to run for? November 2014 to July 2016 Who is funding the study? King's College London (UK) Who is the main contact? Dr Veronica Booth

Critère d'inclusion

• Gingival inflammation

Liens

• ictrp
• isrctn