Diseases [C] - Bacterial Infections and Mycoses [C01] Clinical Trials

295 clinical trials for Diseases [C] - Bacterial Infections and Mycoses [C01] across international registries, including 20 currently recruiting participants. Compare status, phase, eligibility criteria and locations.

• A Phase 2, Multicenter, Randomized, Double-blind Study of Safety and Efficacy of EL219 (Turletricin) versus Liposomal Amphotericin B or Voriconazole for Early Antifungal Therapy of Invasive Mould Infections (TREAT-1) — RECRUITING · PHASE2
• Open-label safety and efficacy trial of chlorhexidine and/or metronidazole pre-treatment followed by FB301 in women with bacterial vaginosis (BV) — RECRUITING · PHASE2
• Dexamethasone for treating severe hospital-acquired pneumonia in critically ill patients with a proinflammatory phenotype, an international phase III, double-blind, placebo-controlled, randomized trial - the HAP-DEX study — RECRUITING · PHASE3
• A Randomized, Multicenter, Single-Blind, Parallel-Group Phase III Non-Inferiority Trial Comparing the Efficacy and Tolerability of a Fixed-Dose Combination of Metronidazole, Bismuth Oxide and Tetracycline HCl to Standard Concomitant Non-Bismuth Quadruple Therapy for First-Line Eradication of Helicobacter pylori in Adults. — RECRUITING · PHASE3
• Adjunctive Hyperbaric Oxygen Treatment for Patients with Necrotizing Soft-Tissue Infection (HOT-NSTI trial) — RECRUITING · PHASE4
• LOVIT-ARDS - A Multicentre Concealed‐Allocation Parallel‐Group Blinded Randomized Controlled Trial to Ascertain the Effect of High‐Dose Intravenous Vitamin C Compared to Placebo on Mortality or Persistent Organ Dysfunction at 28 Days in Septic ARDS Patients — RECRUITING · PHASE3
• A Phase 3 prospective, randomized, multicenter, active-controlled study to evaluate the efficacy and safety of BV100 plus low-dose polymyxin B compared with colistin plus high-dose ampicillin/sulbactam in the treatment of adult patients with hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia caused by carbapenem-resistant Acinetobacter baumannii-calcoaceticus complex — RECRUITING · PHASE3
• Empirical Meropenem versus Piperacillin/Tazobactam for Adult Patients with Sepsis (EMPRESS) trial — RECRUITING · PHASE4
• A Phase 3, randomized, modified double-blind, active-controlled, parallel-group, 2-arm study to investigate the safety and immunogenicity of a 21-valent pneumococcal conjugate vaccine in healthy infants and toddlers — RECRUITING · PHASE3
• PK/PD of Cefadroxil in Staphylococcus Aureus Bacteremia, a preliminary study — RECRUITING · PHASE2
• Enhancing Lung Health in Kids with structural Lung Damage and Malformations: a randomized controlled trial on Azithromycin (AZI) for Airway Infection Prevention — RECRUITING · PHASE4
• A Multi-Center, Open-Label, Single-Arm, Phase 2 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Vabomere (meropenem-vaborbactam) in the Treatment of Children with Complicated Urinary Tract Infection, Including Acute Pyelonephritis — RECRUITING · PHASE2
• A multi-center, single-arm, open-label study to evaluate tolerability, safety, and efficacy of topical MOB015B solution in the treatment of mild to moderate distal subungual onychomycosis (DSO) in subjects aged 6-17 years — RECRUITING · PHASE2
• ISA-PET — RECRUITING · PHASE1
• Effects of mesenchymal stem cells administration on organ failure during septic shock: Phase II randomized comprator-controlled study CHOC-MSC — RECRUITING · PHASE2
• FECES - Fecal transplantation to Eradicate Colonizing Emergent Superbugs — RECRUITING · PHASE3
• RIFAMAB : Rifabutin versus rifampicin for treatment of staphylococcal prosthetic joint infection treated with debridement, antibiotics and implant retention (DAIR strategy): a multicenter randomized, open-label, non-inferiority trial — RECRUITING · PHASE3
• Impact of Albumin on Renal function in critically ill patients with Septic Shock and a high risk of Acute Kidney Injury. A Randomized Controlled Trial. — RECRUITING · PHASE4
• Evaluation of the efficacy of treatment with mucosal bacterial vaccines(autovaccines) versus suppressive antibiotic treatment in subjects with hip or knee prosthesis infections. — RECRUITING · PHASE3
• Pragmatic trial on the safety and tolerability of an optimized dose of rifampicin in tuberculosis patients — RECRUITING · PHASE3
• Efficacy of an empirical treatment with Amoxicillin-clavulanate (AC) compared to the combination Amoxicillin-clavulanate and Ciprofloxacin (AC+C) in the outpatient care of chemotherapy-induced fever in adult haematology patients. AC-CIF Protocol — NOT_YET_RECRUITING · PHASE3
• Phase 1, Open-Label, single arm (Non-comparator) Study to Evaluate the Pharmacokinetics and Safety of a Single Dose of Oral Gepotidacin in Addition to Antibacterial Standard of Care in Pediatric Participants from 2 to less than 12 years of age with a Suspected or Confirmed Bacterial Infection or Receiving Prophylaxis with Antibiotics — NOT_YET_RECRUITING · PHASE1
• A study to assess the safety, and blood levels of CTX-187 after single and repeated intravenous doses in healthy volunteers and patients with bacterial infection — TERMINATED · PHASE1
• Multicenter, randomized, open-label non-inferiority trial, comparing two antibiotic therapy periods (3 versus 7 days) in patients with mild leptospirosis and seen at the hospital in 5 French overseas departments (Martinique, Guadeloupe, French Guiana, Reunion, Mayotte) — NOT_YET_RECRUITING · PHASE2
• Development of an optimized dosing regimen of ceftazidime-avibactam in critically ill patients treated with continuous renal replacement therapy — TERMINATED · PHASE4
• A randomized double-blind clinical trial comparing Hypochlorous Acid and Polyhexamethylene biguanide in treating diabetic foot ulcers — TERMINATED · PHASE3
• Single-centre clinical trial investigating the safety and tolerability of increasing multiple doses of nebulised SS0331 in healthy participants — TERMINATED · PHASE1
• A multicenter, randomized, controlled, open-label, parallel-group clinical trial in men who have sex with men (MSM) and transgender women with risk sexual behaviors for sexually transmitted infections. — NOT_YET_RECRUITING · PHASE4
• BETARGET : Randomized trial of individualizing BETA-lactam taRGET combining therapeutic drug monitoring, minimal inhibitory concentration and model-based dose adjustment, in Intensive Care Units patients with gram negative bacilli infection — NOT_YET_RECRUITING · PHASE3
• Multicentre, randomised, double-blind, placebo-controlled clinical trial to confirm the efficacy, safety, and clinical impact of the mucosal bacterial therapeutic vaccine MV140 in women with non-complicated recurrent urinary tract infections (rUTIs). — NOT_YET_RECRUITING · PHASE3
• C1091009 - A PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLINDED TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, AND IMMUNOGENICITY OF A MULTIVALENT GROUP B STREPTOCOCCUS VACCINE IN HEALTHY PREGNANT WOMEN AND THEIR INFANTS — TERMINATED · PHASE3
• Low Intervention, Open, Multicentric, Phase IV Exploratory Clinical Trial to evaluate new biomarkers for the diagnosis and treatment monitoring of tuberculosis — TERMINATED · PHASE4
• Phase I Safety and Immunogenicity Study of a Multivalent Gonorrhoea Vaccine — TERMINATED · PHASE1
• Randomized open-label controlled trial evaluating a single-dose intravenous Dalbavancin versus standard antibiotic therapy during catheterrelated bloodstream infections due to Staphylococcus aureus [DALICATH] — TERMINATED · PHASE3
• PTX3 genetically stratified randomized double-blinded allocation event-driven clinical trial for antifungal prophylaxis in patients with acute myeloid leukemia — TERMINATED · PHASE4
• A Phase I study to evaluate the Safety, Tolerability, and Pharmacokinetics of BAL2420 in Healthy Adult Subjects — TERMINATED · PHASE1
• A Phase 3, randomized, modified double-blind, active-controlled, parallel-group study to investigate the safety and immunogenicity of catch-up vaccination regimens of a 21-valent pneumococcal conjugate vaccine in healthy infants, toddlers, children, and adolescents — TERMINATED · PHASE3
• VATS or Intrapleural Enzymatic Therapy for patientS with empyema (the VIETS trial) — NOT_YET_RECRUITING · PHASE4
• ASPIC - Antimicrobial Stewardship for Ventilator Associated Pneumonia in Intensive Care — TERMINATED · PHASE3
• A Phase IIIb, Open-label, Multi-center Study to Evaluate the Immunogenicity and Safety of a Booster Dose and Describe the Immune Persistence of MenACYW Conjugate Vaccine with 5- and/or 10-year Booster Doses in Children and Adolescents who had been Primed with MenACYW Conjugate Vaccine as Toddlers — TERMINATED · PHASE3
• A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of VE303 for Prevention of Recurrent Clostridioides difficile Infection: The RestoratiVE303 Study — TERMINATED · PHASE3
• A Randomized controlled open-label phase II trial assessing the efficacy and safety of two-dosing regimens of frozen encapsulated fecal microbiota transfer products with or without an individualized donor selection approach in decolonizing carriers of multi-drug resistant Enterobacteriaceae (RESET-MDR) — COMPLETED · PHASE2
• Fecal microbiota transfer for the secondary prevention of recurrent urinary tract infections in premenopausal women: a phase II trial (FEMITRANS) — TERMINATED · PHASE2
• Efficacy of dalbavancin in osteoarticular infections associated with hip, knee and shoulder prostheses PRO-DALBA — TERMINATED · PHASE2
• Randomized Controlled Trial Assessing the Effectiveness and Safety of Fecal Microbiota Transfer for VRE Eradication in Immunocompromised Patients (EU CTR, Phase II) – VRE-ex — NOT_YET_RECRUITING · PHASE2
• Efficacy and safety of different antimicrobial DURATions for the treatment of Infections associated with Osteosynthesis Material implanted after long bone fractures (DURATIOM). Phase 3 pragmatic multicenter open labelled randomized trial. — TERMINATED · PHASE3
• Protecting late-moderate preterm infants from respiratory tract infections and wheeze in their first year of life by using bacterial lysates — TERMINATED · PHASE3
• DOXYCYCLINE PENETRATION INTO BONE AND JOINT. — NOT_YET_RECRUITING · PHASE2
• A study to investigate the repeat-dose pharmacokinetics of a combined oral contraceptive when given alone and in combination with ganfeborole in female participants of non-childbearing potential. — NOT_YET_RECRUITING · PHASE1
• Clindamycin for the treatment of infections: the influence of rifampicin and obesity on PK/PD target attainment — TERMINATED · PHASE4

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