Development of a blOOdtest for uteRine Sarcoma - Diagnosis (DOORS-D)
Uterine sarcomas and uterine fibroids
Development of a blood test to improve the diagnostic process This project aims to pilot the use of a ctDNA-based test to help identify patients who have or do not have a uterine sarcoma. We will recruit patients who are due to undergo surgery for a large fibroid or suspected of having a uterine sarcoma. We will collect information from investigations that are performed before surgery, including scan images (ultrasound/magnetic resonance imaging (MRI)/computer tomography (CT)/positron emission tomography (PET) MRI/CT/PET scans), blood test results, and biopsies from the endometrium (womb lining). A sample of blood will be taken before the planned surgery for ctDNA analysis and compared with the outcome from surgery. A number of participants will also be invited to take part in an interview to discuss their experiences in the study and their views on the potential for a blood test to diagnose uterine sarcomas.
1. Due to undergo surgery (hysterectomy or myomectomy) for a suspected uterine sarcoma or an abnormally appearing fibroid 2. Aged 18-99 years 3. Female 4. Willing and able to consent to participate in the trial
1. Not undergoing surgery (hysterectomy or myomectomy) for a suspected uterine sarcoma or abnormal appearance fibroid 2. Male 3. Not willing and able to consent to participate in the trial 4. Unable to understand the study requirements despite interpreter support