Recording Antimicrobial Resistance during Death Certification in England
Antimicrobial resistance effect on mortality
This will be a retrospective observational cohort study. Eligible patients will be identified through the Civil Registrations of Death database provided by NHS England and will be linked to the HES database, also held by NHS England, to obtain additional clinical metadata. Pseudonymised cases will be subsequently linked to the SGSS database (AMR module) held by UKHSA in order to detect clinical samples with AMR pathogens of interest within 28 days of the patient’s death. Anonymised results will be analysed using a standardized pathway to determine whether each death was AMR-associated. The rate and total number of deaths associated with AMR in this cohort, the most important pathogens, pathogen drug-combinations and resistance mechanisms will be described.
All patients who had their death registered in England between 01/01/2021 and 31/12/2023 will be included in this study.
Only patients who had expressed the wish for their data not to be used for research purposes under the National Data Opt-Out (DOO) will be excluded.