A double-blind, placebo-controlled, randomised, multi-centre, dose-ranging study to determine the safety and efficacy of three concentrations of topical diltiazem cream in the treatment of chronic anal fissure To determine whether topical application of diltiazem cream is superior to placebo in relieving pain associated with anal fissure.

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A Two-Arm Chemoprevention Trial in Familial Adenomatous Polyposis Coli Patients Using the Purified Free Fatty Acid, Eicosapentaenoic Acid To determine whether the polyp burden of patients with genetically determined colorectal polyp syndrome (namely Familial Polyposis Coli) be reduced by regular treatment with high concentration eicosap...

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A double-blind, randomised, placebo-controlled study to evaluate topical 10%phenylephrine gel applied peri-anally in the management of ileal pouch anal anastomosis (IPAA)-related faecal incontinence The primary objective is to determine the effect of 10% phenylephrine hydrochloride gel, applied three times a day, on the change from baseline to the end of study in the faecal incontinence score (St...

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The effect of two dose levels of eicosapentaenoic acid EPA on apoptosis and cell proliferation in the colonic mucosa in patients with a history of colonic polyps To measure levels of apoptosis and cell proliferation in the colonic mucosa of patients with a history of colorectal adenomas before and after treatment with EPA.

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Clinical trial to show the safety and efficacy of Diltiazem hydrochloride cream used for treatment of anal fissure To determine the efficacy of diltiazem hydrochloride cream in reducing pain associated with AF.

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An open label study to determine the safety and tolerability of two dose escalation treatment regimens with an oral, delayed release preparation of nicotine in patients with stable ulcerative colitis maintained by steroid therapy The primary objective is to establish an appropriate dosing schedule that is well-tolerated for oral, delayed-release nicotine capsules in subjects with mild-to-moderate stable UC.

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