Restoring Dystrophin Expression in Duchenne Muscular Dystrophy: A Phase I/II Clinical Trial Using AVI-4658 The purpose of this trial is to evaluate the safety and tolerability of a single intramuscular (IM) dose of AVI-4658, a phosphorodiamidate Morpholino oligomer (PMO) at increasing dosages compared to p...

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Trial comparing two diabetes medications (Gliclazide versus Linagliptin) on frequency of low blood sugar levels in patients with Type 2 Diabetes and chronic moderate to severe kidney disease Background and study aims Type 2 diabetes mellitus (T2DM) is a growing problem worldwide. People with T2DM have difficulty controlling their blood sugar (glucose) as they do not produce enough insuli...

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Assessment of the palatability of elemental nutritional supplements compared to non-elemental supplements in people with pelvic cancers and people without cancer, and whether this changes following treatment with radiotherapy Not provided at time of registration

• Pays United Kingdom
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LeoPARDS - An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis The main objectives of this trial are: 1. To ascertain if levosimendan reduces the incidence and severity of organ failure as compared to placebo in adult patients who have septic shock. 2. To ident...

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Mechanistic study assessing the immunological response of subjects after treatment with different formulations of sublingual immunotherapy To evaluate the immunological response in subjects with grass pollen induced allergic rhinoconjunctivitis after 8 weeks of once daily dosing with sublingual immunotherapy, either Alutard SQ Phleum pra...

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INFLUENCE OF THE ANTIOXIDANT N-ACETYLCYSTEINE ON INHALED NITRIC OXIDE INDUCED PULMONARY RESPONSES FOLLOWING HUMAN LUNG ISCHAEMIA-REPERFUSION INJURY The primary objective of the trial is to assess the influence of increasing concentrations of inhaled NO on pulmonary gas exchange and pulmonary arterial pressures and vascular resistance prior to and...

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Effect of singing lessons on physical activity in patients with Chronic Obstructive Pulmonary Disease (COPD) Not provided at time of registration

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A phase I/II safety and tolerability dose escalation study following the autologous infusion of expanded adult haemopoietic stem cells to patients with liver insufficiency To determine the maximum tolerated dose of expanded autologous cells derived from a subset of CD34+ stem cells when infused into either the hepatic artery or the portal vein. The trial will also seek...

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Cognitive behaviour therapy for excessive worry over health in medical patients Background and study aims Hypochondriasis, or health anxiety, is a significant problem in all parts of clinical practice, but has been largely ignored by services until recently. Our studies, and thos...

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The effects of liraglutide in controlling blood sugar and weight in poor-responders to bariatric surgery Background and study aims Type 2 diabetes mellitus (T2DM) is a growing problem worldwide. People with T2DM have difficulty controlling their blood sugar (glucose) as they do not produce enough insulin...

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