A Global, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Comparing the Safety and Efficacy of ABT-894, Duloxetine and Placebo in Subjects with Diabetic Neuropathic Pain To compare the analgesic efficacy and the safety of ABT-894 (1 mg, 2 mg, or 4 mg capsules) administered twice daily (BID) to placebo in the treatment of diabetic neuropathic pain (DNP). Duloxetine 60...

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An Open-Label, Randomized Phase 2 Study of ABT-869 in Combination With mFOLFOX6 (Oxaliplatin, 5-Fluorouracil, and Folinic Acid) Versus Bevacizumab in Combination With mFOLFOX6 as Second-line Treatment of Subjects With Advanced Colorectal Cancer To assess if the addition of oral ABT-869 to mFOLFOX6 (5-fluorouracil, folinic acid, and oxaliplatin) can prolong progression-free survival (PFS) compared to bevacizumab plus mFOLFOX6 as second-line t...

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A Multi-Centre, Randomized, Double-Blind, Placebo-Controlled Study of the Human Anti-TNF Monoclonal Antibody Adalimumab for the Induction of Clinical Remission in Subjects with Moderate to Severe Crohn's Disease who Have Lost Response or are Intolerant to Infliximab To demonstrate the efficacy of adalimumab in the treatment of subjects with Crohn's disease who either initially responded to administration of infliximab but stopped responding or were intolerant to ...

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A double-blind, placebo-controlled study to evaluate the safety and effect of three experimental drugs ABT-450, ABT-267, and ABT-333 with or without ribavirin in people with hepatitis C virus (HCV) that have not been treated before. "Experimental" means that they have not been approved by any regulatory agency for sale to the public The primary objective of this study are to compare the efficacy (SVR12) and safety of the combination of ABT-450/r/ABT-267 and ABT-333 administered with and without RBV for 12 weeks in treatment-naive...

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A Multi-Center, Open-Label Study of the Fully Human Anti-TNF Monoclonal Antibody Adalimumab for the Induction and Maintenance of Clinical Remission in Subjects with Moderate to Severe Crohn's Disease To evaluate and delineate the safety and efficacy profile of adalimumab (HUMIRA pre-filled syringe or HUMIRA pre-filled PEN) when administered to subjects with moderate to severe Crohn´s Disease.

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The PRIMO Study: Paricalcitol Capsules benefits in Renal failure Induced cardiac Morbidity in Subjects with Chronic Kidney Disease Stage 3B/4. Estudio Primo: Beneficios de Paricalcitol cápsulas sobre la morbilidad cardíaca provocada por la insuficiencia renal en los sujetos con enfermedad renal crónica en estadios 3B/4 To investigate the effects of paricalcitol capsules on progression or regression of LVH in subjects with Stage 3B/4 CKD compared to placebo, as assessed by comparing changes in LV Mass Index (LVMI) ov...

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A Phase 1/2 Study Evaluating the Safety and Efficacy of ABT-751 in Combination with Pemetrexed Versus Pemetrexed Alone in Subjects with Advanced or Metastatic Non-Small Cell Lung Cancer The primary objective of the Phase 1 portion of the study, which will be conducted in the US only, is to determine the maximum tolerated dose (MTD) of ABT-751 when administered daily for 14/21 days, i...

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A Multicenter, Randomized, Double-Period, Double − Blind Study to Determine the Optimal Protocol for Treatment Initiation with Methotrexate and Adalimumab Combination Therapy in Patients with Early Rheumatoid Arthritis The objective of this study is to assess and compare the proportion of subjects who achieve low disease activity as defined by both a clinical response (DAS28<3.2) and no radiographic progression (∆mT...

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A Clinical Trial of ABT-888 in Combination with Temozolomide Versus Pegylated Liposomal Doxorubicin Alone in Subjects with Recurrent High Grade Serous Ovarian Cancer To evaluate the objective response rate (ORR) of ABT-888 in combination with Temozolomide (TMZ) compared to Pegylated Liposomal Doxorubicin (PLD) alone in subjects with recurrent high grade serous ova...

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Estudio fase III, aleatorizado, abierto de Lopinavir/ritonavir comprimidos versus cápsulas de gel blando y su administración una vez al día versus dos veces al día, cuando se coadministran con ITIAN, en sujetos infectados por el VIH-1 sin tratamiento antirretroviral previo. A Phase 3, Randomized, Open-label, Study of Lopinavir/ritonavir Tablets Versus Soft Gel Capsules and Once Daily Versus Twice Daily Administration, when Coadministered with NRTIs in Antiretroviral Naïve HIV-1 Infected Subjects The primary objectives of this study are: ● To compare the safety and tolerability of the to-be-marketed lopinavir/ritonavir tablet formulation with the marketed SGC formulation. ● To compare the safe...

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