Randomised Trial of Rituximab in C4d+ Chronic Renal Transplant Rejection To determine whether anti-CD20 therapy can stabilise or improve renal function and/or proteinuria in patients with C4d+, chronic (humoral) rejection in whom standard therapeutic approaches have failed...

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Lixisenatide Arterial Stiffness Trial To evaluate if treatment with Lixisenatide for 24 weeks reduces Ao-PWV in T2DM with DN.

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Depression: a trial of antenatal guided self help for women Background and study aims Pregnancy does not appear to be protective against the existing or development of new mental disorders. Depression is the most common antenatal mental disorder and can hav...

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A pilot study to investigate the effect of reactivity to brief alcohol assessment on subsequent consumption, problems and dependence Not provided at time of registration

• Pays United Kingdom
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Cognitive training in robotic surgery Background and study aims In recent years surgical training has had to undergo big changes. Introduction of the European working times directive has limited the amount of training time for surgeons an...

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A trial to determine if rifaximin is more efficient than placebo in treating systemic inflammation and neutrophil (white blood cells) malfunction in patients with cirrhosis and chronic hepatic encephalopathy To test if rifaximin reduces neutrophil spontaneous oxidative burst ex vivo in patients with cirrhosis and chronic hepatic encephalopathy after 30 days.

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Improving Well-being and HEaLth for people with Dementia Background and study aims 800,000 people in the UK have dementia, of which 250,000 are living in care homes. These people have complex mental health problems, disabilities and social needs, which nee...

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This study aims to investigate the potential beneficial effects on the kidney of a new medication called Dapagliflozin in type 2 diabetic patients To study the potential protective role of Dapagliflozin on renal disease in patients with Type 2 diabetes and diabetic renal disease. We aim to evaluate in this trial if the combination of Dapaglifloz...

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Trial to study the use of injectable buprenorphine in patients who persist in using illicit heroin to find an acceptable dose that could help reduce the use of illicit heroin The trial aims to examine the safety, acceptability, and physiological responses to high dose injectable buprenorphine, for subjects not responding to their current maintenance treatment. The key out...

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Cognitive behaviour therapy for epilepsy: improving seizure control and quality of life Not provided at time of registration

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