Sequential treatment with Cytoreductive therapy & transplant for Relapsed/ Refractory Acute Myeloid Leukemia, High Risk Myelodysplasia,or other High Risk Myeloid Malignancies To determine whether it is safer and more effective, in treating high risk Myeloid Malignancies, to immediately follow chemotherapy with Allogeneic Haemopoietic Stem Cell Transplantation than to treat...

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A multicentre double-blind randomised controlled trial to assess the clinical- and cost-effectiveness of facet- joint injections in selected patients with non-specific low back pain: A feasibility study To assess the feasibility of conducting a definitive study to evaluate the clinical- and cost-effectiveness of facet-joint injections compared to a sham procedure, in patients with non-specific low ba...

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RANDOMISED, MULTI-CENTRE, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF VITAMIN D SUPPLEMENTATION IN ADULT AND ADOLESCENT PATIENTS WITH ASTHMA Does vitamin D supplementation influence time to first severe exacerbation and time to first upper respiratory tract infection in patients with asthma?

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A Single Arm Phase II Study to assess the efficacy of intensified intravenous Melphalan in combination with a transplant of the patient's own blood stem cells for a maximum of three cycles in patients with castration-resistant prostate cancer (CRPC) To determine the efficacy of intensified intravenous melphalan with autologous whole blood stem cell transplantation in patients with Castration-resistant prostate cancer using Progression Free Survi...

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TREATMENT OF IRON DEFICIENCY ANAEMIA IN ADOLESCENTS WITH INFLAMMATORY BOWEL DISEASE Is there a difference in the response to treatment with iron supplementation in adolescents and adults in IBD? We hypothesise that there is no difference in the haematological response to treatme...

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Randomised, Multi-Centre, Double-Blind, Placebo-Controlled Trial of Vitamin D Supplementation in Patients with Chronic Obstructive Pulmonary Disease Does Vitamin D supplementation influence time to first moderate / severe exacerbation and time to first upper respiratory tract infection in patients with COPD?

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Cluster-randomised, Double-Blind, Placebo-Controlled Trial of Vitamin D Supplementation for the Prevention of Influenza and other Respiratory Infections in Sheltered Accommodation (ViDiFlu) Does high-dose vitamin D supplementation prevent influenza and other respiratory infections in sheltered accomodation residents and staff?

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A study to investigate the effectiveness of performing a nerve block on patients suffering from chronic migraines The primary objective of this study, is to investigate any change in disability associated with chronic migraine disorder in the two treatment arms (greater occipital nerve block versus placebo proced...

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Comparison of the fixed versus the removable functional braces in the treatment of children with sticking out top front teeth Background and study aims Sticking out top front teeth is a very common problem amongst children in the UK, and is caused by incorrect alignment of the top and bottom jaws (malocclusion). This can res...

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Mindfulness meditation for chronic pelvic pain management Background and study aims Chronic pelvic pain (CPP) in women is where pain is felt in the pelvic region (the area below the belly button and between the hips) for at least 6 months. It is a relatively...

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