Efficacy of a web-based competitive intervention to promote physical activity Background and study aims: This study aims to assess how well two web-based treatments promote physical activity compared to a group who are not provided the web-based treatments (control group). Phy...

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AN OPEN LABEL STUDY OF THE EFFECT OF TREATMENT WITH RITUXIMAB ON RESISTANT RHEUMATOID ARTHRITIS: Clinical, radiological, synovial and immunological outcomes To confirm the efficacy and safety of rituximab in patients with resistant RA

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What is the ED95 dose for bupivacaine for supraclavicular brachial plexus block using ultrasound? What is the ED95 dose of 0.5% bupivacaine for supraclavicular brachial plexus nerve block using ultrasound?

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Fibroblast growth factor receptors (FGFR) Inhibition for Epithelial Solid Tumours Dose Escalation Cohort To investigate the safety, tolerability and feasibility of the novel AGC (AZD4547 with gemcitabine and cisplatin) combination in advanced non-haematological malignancies. Random...

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Detecting early pre-symptomatic psoriatic arthritis in patients with skin moderate or severe psoriasis - how effective is ustekinumab (Stelara) in limiting joint disease progression and future disability? Do the imaging features of subclinical enthesopathy (the earliest change seen in psoriatic arthritis), as measured by peripheral joint ultrasound (USS) and whole body MRI, in patients with moderate-to...

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Risk reduction intervention of cardiovascular disease in China Background and study aims Cardiovascular disease (CVD, disease of the heart and/or blood vessels) remains one of the main causes of death worldwide. One of the main factors contributing to CVD is rai...

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A randomised controlled trial to compare withdrawal of therapy versus continuing therapy in low disease states in psoriatic arthritis – feasibility study For this feasibility study we wish to know the proportion of eligible patients who are willing to undergo treatment withdrawal and the proportion remaining in minimal disease at the end of the study p...

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Pain Reduction in Osteoarthritis of the knee using oral Methotrexate Not provided at time of registration

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Delivering enhanced cardiovascular disease and hypertension care through private health facilities in Pakistan Background and study aims Over 80% of cardiovascular deaths take place in low- and middle-income countries but despite convincing evidence that lowering of blood pressure decreases cardiovascular dise...

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Enhanced diabetes-cardiovascular management through primary health care in Pakistan Background and study aims Diabetes is a lifelong condition that causes a person's blood sugar level to become too high. Pakistan ranks seventh among the global top ten countries with highest number of...

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