“What is the ED95 dose of Prilocaine for femoral nerve block using ultrasound?” To find out the ED95 of 1% prilocaine for femoral nerve block using ultrasound.

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ASUS: Abatacept in Seronegative Undifferentiated arthritis Study Prospective, Single-centre, Pilot Study Assessing the Efficacy of Abatacept in Anti-CCP Negative Undifferentiated Inflammatory Arthritis To assess the proportion of subjects with CCP-negative, power Doppler positive Undifferentiated Arthritis who on open-label Abatacept medication achieve the following criteria at 6 months: 1. DAS44 re...

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Safety and efficacy of combination treatment with rituximab and leflunomide in patients with active rheumatoid arthritis Primary objective is to assess safety of rituximab combined with leflunomide. Safety will be evaluated by the frequency of Adverse Events and the outcome of laboratory blood monitoring.

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A multicentre randomised trial of etanercept and methotrexate to induce remission in early inflammatory arthritis Not provided at time of registration

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A multi-centre randomised double dummy double blind study comparing two regimens of combination induction therapy in early DMARD naive Rheumatoid Arthritis: The IDEA study (Infliximab as Induction Therapy in Early Rheumatoid Arthritis) To determine whether use of Biologic Therapy (infliximab) as induction therapy in early rheumatoid arthritis results in less radiographic damage over 78 weeks compared to current best practice therapy...

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CLASS Trial: Evaluation of a school-based intervention to protect children from second-hand smoke Not provided at time of registration

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REO13 Brain - A study to evaluate the effects of intravenous injection of reovirus in patients prior to planned surgical removal of aggressive brain tumours that have relapsed, or tumours that have spread to the brain from elsewhere in the body http://www.cancerresearchuk.org/cancer-help/trials/a-study-looking-effects-drug-reolysin-people-cancer-affecting-brain-reo-13-brain

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ReoGlio: REOLYSIN® plus GM-CSF in combination with standard of care chemotherapy and radiotherapy for patients with glioblastoma multiforme (GBM) Lay summary under review with external organisation

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Tocilizumab and Remission in early rheumatoid arthritis Tocilizumab (TCZ) is an anti-IL6 receptor monoclonal antibody. IL6 is a pro-inflammatory cytokine. Dyregulated production of this cytokine is implicated in the pathogenesis of rheumatoid arthritis (RA...

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Biting contacts before and after treatment of worn teeth Background and study aims The management of worn upper and/or lower anterior (front) teeth is a challenge, as the teeth often become much shorter in length. This affects the appearance and function, a...

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