RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PHASE III, SUPERIORITY TRIAL TO ASSESS THE EFFICACY AND SAFETY OF ACETYL-L-CARNITINE IN COMBINATION WITH A CISPLATIN CONTAINING CHEMOTHERAPY AS FIRST LINE TREATMENT OF ADVANCED OR METASTATIC NON SMALL CELL LUNG CANCER To compare toxicity free survival of patients treated with ALC plus cisplatin-containing CHT versus those treated with placebo plus cisplatin-containing chemotherapy.

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Clinical trial designed to compare the metabolic effects of Telmisartan compared with Losartan in patients with renal transplantation Studio clinico volto a confrontare gli effetti metabolici di Telmisartan rispetto a Losartan in pazienti con trapianto renale To compare the short-term effects of telmisartan and losartan on insulin sensitivity in kidney transplant recipients with stable renal function and concomitant treatment with steroids and/or calcineur...

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DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL ON THE USE OF ACETYL-L-CARNITINE FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) Assessment of the impact of LAC at the dose of 3g/day by oral route for 12 consecutive months on the disability of ALS, in a clinically significant and measurable way

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ITACA-S 2 (Intergroup Trial in Adjuvant Chemotherapy for Adenocarcinoma of the Stomach): comparison of the efficacy of a peri-operative versus a post-operative chemotherapy treatment in patients with operable gastric cancer and assessment of the benefit of a post-operative chemo-radiotherapy The study addresses two primary questions, according to its factorial design: to compare the efficacy in terms of OS of a peri-operative vs. a post-operative CHT treatment, irrespectively of the pr...

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A PILOT, EXPLORATIVE STUDY TO IDENTIFY CONTRAST-ENHANCED ULTRASOUND (CE-US) PATTERNS THAT CHARACTERIZE ACUTE ALLOGRAFT REJECTION AND OTHER CAUSES OF ACUTE ALLOGRAFT DYSFUNCTION IN RENAL TRANSPLANT RECIPIENTS To identify the patterns of kidney graft perfusion that are associated with key patterns of renal involvement that may be detected in patients with acute allograft dysfunction. For the purposes of the...

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Sirolimus treatment in patients with autosomal dominant polycystic kidney disease renal efficacy and safety The general aim of this randomized, open, cross-over study is to assess the efficacy and safety of 6 month treatment with sirolimus on the top of the best available therapy as compared to convention...

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A phase III study to determine whether Cyclosporine A improves outcomes after successful primary angioplasty, by improving myocardial reperfusion. Studio di fase III per verificare se Ciclosporina A puo' migliorare l'esito di un infarto miocardico acuto riperfuso con successo mediante angioplastica primaria, favorendo la riperfusione miocardica The primary objective of the present study is improvement of myocardial reperfusion, measured with ST-segment resolution >=70% 1 hour after PCI. Obiettivo primario di questo studio è il migliora...

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Efficacy of nebulised beclometasone versus placebo in preventing viral wheezing in pre-school children To evaluate the efficacy of beclometasone in preventing wheezing in respiratory tract infection.

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A PROSPECTIVE, PILOT, CROSS-OVER STUDY TO ASSESS THE EFFICACY OF PARICALCITOL IN REDUCING PARATHYROID HORMONE LEVELS AND AMELIORATING MARKERS OF BONE REMODELLING IN RENAL TRANSPLANT RECIPIENTS WITH SECONDARY HYPERPARATHYROIDISM (APPLE STUDY) To evaluate whether 6-months treatment with paricalcitol may achieve a prompt and effective reduction in PTH serum levels in stable renal transplant patients with secondary hyperparathyroidism.

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A PROSPECTIVE STUDY TO ASSESS THE INTERACTION BETWEEN PATIENT GENOTYPE AND ROSTAFUROXIN EFFECTS ON ARTERIAL BLOOD PRESSURE AND KIDNEY FUNCTION IN NEVER-TREATED HYPERTENSIVE TYPE 2 DIABETES PATIENTS (AN OPEN LABEL STUDY WITH BLINDED PATIENT GENOTYPE) STUDIO DELL'INTERAZIONE TRA GENOTIPO ED EFFETTO DELLA ROSTAFUROXINA SU PRESSIONE ARTERIOSA E FUNZIONALITA' RENALE IN PAZIENTI CON DIABETE TIPO 2 ED IPERTENSIONE ARTERIOSA MAI TRATTATA To compare the reduction in office systolic BP and albuminuria (mean of three consecutive measurements in 24-hour urine collections) after 5 weeks Rostafuroxin therapy between two subsets of hypertens...

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