Estudio fase III, no aleatorizado, abierto para evaluar la seguridad e inmunogenicidad de la vacuna H1N1 adyuvada con AS03A administrada como primovacunación y booster en sujetos entre 3 y 17 años de edad Evaluar la respuesta inmune humoral después la administración de dos dosis primarias de la vacuna pandémica experimental H1N1 que alcance o exceda los objetivos normativos (CPMH) de la AEM para la ta...

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A double-blind, randomized, placebo-controlled, multi-centre, dose-ranging, parallel group, phase II study to assess efficacy, safety/tolerability, and pharmacokinetics of a thrombopoietin receptor agonist, SB-497115-GR, when administered as 30, 50, and 75 mg once daily for 12 weeks in subjects with chronic hepatitis C–related thrombocytopenia who are potential candidates for antiviral treatment with pegylated interferon and ribavirin 1. To evaluate the effects of SB-497115-GR on platelet counts when administered once daily for 4 weeks (Part 1) to subjects with chronic hepatitis C-related thrombocytopenia, prior to receiving antiv...

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A study of dabrafenib with trametinib in patients with melanoma Estudio de dabrafenib con trametinib en pacientes con melanoma To evaluate biomarkers linked to treatment response, resistance and toxicity including skin toxicity when dabrafenib and trametinib combination is given upfront or as monotherapy before the combinatio...

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A Randomised, Double-Blind, Placebo-Controlled, Parallel Group, Multicentre, Long-Term Study to Evaluate the Safety of Once-Daily, Intranasal Administration of GW685698X Aqueous Nasal Spray 100mcg for 52 Weeks in Adult and Adolescent Subjects with Perennial Allergic Rhinitis The primary objective of this study is to assess the safety and tolerability of 12 months treatment with intranasal GW685698X 100mcg once daily (QD) in subjects >=12 years of age with PAR.

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An Eight-Week, Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging Study to Evaluate Efficacy and Safety of Talnetant in Subjects with Irritable Bowel Syndrome The primary objective is to determine whether talnetant provides adequate relief of IBS pain and discomfort in any dose group compared to placebo and to determine the safety and tolerability in IBS su...

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Estudio fase IV, multicéntrico, randomizado, doble ciego de 52 semanas de tratamiento, con un periodo de seguimiento abierto de 24 semanas, para evaluar el efecto de Avandia® sobre el tejido óseo de mujeres posmenopáusicas con Diabetes Mellitus tipo 2- A 52 Week Randomized, Double-Blind, Multicenter, Mechanistic Study with a 24 Week Open-Label Follow-Up to Evaluate the Effect of AVANDIA™ on Bone in Postmenopausal Women with Type 2 Diabetes Mellitus Estimar la diferencia porcentual media en la DMO del cuello femoral, medida por DXA, desde el período basal hasta la semana 52 dentro del grupo tratados con Avandia.

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A randomised, placebo-controlled, parallel group single dose study of GW856553 in patients with active RA to investigate the CRP dose response relationship. Estudio aleatorizado, de grupos paralelos y controlado con placebo de la administración de una dosis única de GW856553 en pacientes con Artritis Reumatoide activa para investigar la relación entre la dosis y respuesta sobre la proteína C reactiva • To describe the single dose response relationship of the dose range of 7.5 to 60mg of GW856553 on circulating serum CRP levels

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A trial to understand whether GSK1070806 improves renal transplant function immediately and in the long term after transplantation Ensayo para entender si GSK1070806 mejora la función renal tras el trasplante a corto y largo plazo To assess the frequency of delayed graft function (DGF) in donation after circulatory death (DCD) renal transplant recipients treated with GSK1070806. Determinar la frecuencia de retraso a la fu...

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Clinical Research Study to compare Umeclidinium/Vilanterol, Umeclidimium, and Salmeterol in subjects with chronic obstructive pulmonary disease (COPD). Estudio clínico para comparar umeclidinio/ vilanterol, umeclidinio y salmeterol en sujetos con enfermedad pulmonar obstructiva crónica (EPOC) To compare the effect of UMEC/VI (62.5/25 mcg once daily) with UMEC (62.5 mcg once daily) on lung function. Comparar el efecto de UMEC/VI (62,5/25 μg una vez al día) con el de UMEC (62,5 μg una ...

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A study to evaluate safety, reactogenicity and immunogenicity of GSK Biologicals’ RSV investigational vaccine based on viral proteins encoded by chimpanzee-derived adenovector (ChAd155-RSV) (GSK3389245A) in RSV-seropositive infants Estudio para evaluar la seguridad, la reactogenicidad y la inmunogenicidad de la vacuna experimental frente al virus respiratorio sincitial (VRS) de GSK Biologicals basada en proteínas virales codificadas por un adenovector derivado del chimpancé (ChAd155 RSV) (GSK3389245A) en niños seropositivos frente al VRS To evaluate the safety and reactogenicity of three dose levels of the RSV investigational vaccine when administered as two IM doses according to a 0, 1-month schedule, up to 30 days after Dose 2 (i.e....

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